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Pre-1900

6 medications

Aspirin

NSAID1899

The original modern drug, synthesized by Felix Hoffmann at Bayer in 1897. Aspirin treats pain, fever, and infl...

Morphine

Opioid1827

The gold standard opioid analgesic, isolated from opium by Friedrich Serturner in 1804. Morphine treats severe...

Codeine

Opioid1832

A naturally occurring opioid found in opium in smaller amounts than morphine. Codeine treats mild to moderate ...

Smallpox Vaccine

Vaccine1796

The first successful vaccine, developed by Edward Jenner in 1796. Jenner noticed that milkmaids who caught cow...

Rabies Vaccine

Vaccine1885

Developed by Louis Pasteur in 1885, the rabies vaccine was the second vaccine developed for humans, after smal...

Cholera Vaccine

Vaccine1892

One of the earliest vaccines, developed for cholera, a waterborne bacterial infection causing severe diarrhea....