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Heparin

Anticoagulant1937
Drug ClassAnticoagulant
Year Approved1937
Conditions TreatedBlood clots, surgery
AvailabilityPrescription

About Heparin

An injectable anticoagulant discovered in 1916 by Jay McLean, a medical student. Heparin prevents blood clots during surgery, dialysis, and in hospitalized patients. It works by activating antithrombin, which inhibits thrombin and factor Xa. Heparin is fast acting and rapidly reversed by protamine sulfate. A dangerous side effect is heparin induced thrombocytopenia or HIT, which paradoxically causes blood clots. Heparin is on the WHO essential medicines list and remains essential for hospital care.

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