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Isotretinoin

Retinoid1982
Drug ClassRetinoid
Year Approved1982
Conditions TreatedSevere acne
AvailabilityPrescription

About Isotretinoin

A powerful oral retinoid for severe cystic acne. Isotretinoin or Accutane treats nodular acne that has not responded to other treatments. It often produces long lasting remission of acne. Isotretinoin is highly teratogenic, causing severe birth defects. In the US, the iPLEDGE program requires pregnancy testing and contraception for patients who can become pregnant. The drug can cause dry skin, mood changes, and elevated liver enzymes. Despite risks, isotretinoin is transformative for severe acne, changing lives of patients with disfiguring cystic acne.

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