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Early 20th Century

24 medications

Penicillin

Antibiotic1942

Discovered by Alexander Fleming in 1928 when mold contaminated his petri dish. Penicillin revolutionized medic...

Chloramphenicol

Antibiotic1949

A broad spectrum antibiotic discovered in a Venezuelan soil sample. Chloramphenicol was once widely used but i...

Streptomycin

Antibiotic1944

The first effective treatment for tuberculosis, discovered by Albert Schatz and Selman Waksman. Streptomycin i...

Bacitracin

Antibiotic1945

A topical antibiotic used in over the counter ointments for minor cuts and scrapes. Bacitracin is produced by ...

Neomycin

Antibiotic1949

An aminoglycoside antibiotic used topically for skin infections and orally for bowel preparation before surger...

Oxycodone

Opioid1917

A semisynthetic opioid derived from thebaine, a component of opium. Oxycodone treats moderate to severe pain. ...

Hydrocodone

Opioid1923

Long one of the most prescribed opioids in the United States. Hydrocodone treats moderate to severe pain and i...

Methadone

Opioid1947

A long acting synthetic opioid used for two purposes: treating opioid addiction and managing chronic pain. Met...

Heparin

Anticoagulant1937

An injectable anticoagulant discovered in 1916 by Jay McLean, a medical student. Heparin prevents blood clots ...

Digoxin

Cardiac Glycoside1930

A cardiac glycoside derived from the foxglove plant. Digoxin treats heart failure and controls heart rate in a...

Insulin

Hormone1922

The discovery of insulin by Banting and Best in 1921 transformed diabetes from a death sentence into a managea...

Influenza Vaccine

Vaccine1945

One of the most widely used vaccines, given to hundreds of millions of people each year. Flu vaccine effective...

Tetanus Vaccine

Vaccine1924

A vaccine against tetanus, a bacterial infection causing severe muscle spasms. Tetanus bacteria are found in s...

BCG Vaccine

Vaccine1921

The Bacillus Calmette Guerin vaccine against tuberculosis, developed by Albert Calmette and Camille Guerin. BC...

Yellow Fever Vaccine

Vaccine1938

A vaccine against yellow fever, a mosquito borne viral disease found in tropical Africa and South America. The...

Theophylline

Bronchodilator1902

A methylxanthine bronchodilator used for asthma and COPD since the early 20th century. Theophylline relaxes ai...

Testosterone

Androgen1935

The primary male sex hormone. Testosterone treats male hypogonadism, a condition where the body produces insuf...

Diphenhydramine

Antihistamine1946

A first generation antihistamine marketed as Benadryl. Diphenhydramine treats allergic reactions, hives, and i...

Lidocaine

Anesthetic1948

A local anesthetic that blocks nerve signals. Lidocaine or Xylocaine is the most widely used local anesthetic ...

Phenytoin

Anticonvulsant1938

One of the oldest antiseizure medications. Phenytoin or Dilantin treats tonic clonic seizures and status epile...

Dimercaprol

Chelating Agent1941

A chelating agent developed during World War II as an antidote to arsenic based chemical weapons. Dimercaprol ...

Dapsone

Antibiotic1949

A medication originally developed for leprosy that is now used for multiple skin conditions. Dapsone or DDS tr...

Hyoscyamine

Antispasmodic1930

An anticholinergic medication that relieves smooth muscle spasms. Hyoscyamine or Levsin treats intestinal cram...

Polymyxin B

Antibiotic1947

A last resort antibiotic for multidrug resistant gram negative infections. Polymyxin B belongs to an old class...